With more than 120 wineries, breweries and distilleries spread across the Finger Lakes region in upstate New York, you'll likely need more than a weekend to discover all that the area has to offer. If you're short on time, focus on the three largest lakes: Keuka, Seneca and Cayuga. While Riesling is the most famous varietal produced in the region, wineries here are on a mission to not only perfect their whites but also prove they can compete with bold reds reminiscent of European labels. Plus, a trip to this part of the state means you'll get to experience the bounty of produce available from the many farms that neighbor each vineyard.